the Whole Story of Finasteride

the Origins of Finasteride as a prescription drug

 

Post Finasteride Syndrome is a condition that is observed to occur in patients taking Finasteride/Proscar/Propecia and even saw palmetto. The symptoms are usually observed to be sexual, physical and neurological, and are known to continue or even start after discontinuing use of the hair loss drug or supplement itself.

Many men have quietly gone back to their lives, some have chosen suicide, and others are still searching for potential treatments to the side effects of 5-AR inhibitors. Since it is widely held that the syndrome is a result of treatment for hair loss using Finasteride, it is important to understand its origins, which could reveal why the drug affects the male body the way it does overall.  

What is Finasteride?

Finasteride is a commonly used 5 - alpha reductase inhibitor. The United States Food and Drug Administration approves the use of Finasteride for Androgenic alopecia ( A G A ) and benign prostatic hypertrophy (BPH). Due to the selectiveness of Finasteride as an inhibitor of 5 - alpha reductase Type I I. Postfinasteride symptomology is quite varied.  

Clinical tests reportedly show that patients treated with Finasteride show symptoms of erectile dysfunction, decreased libido, ejaculation disorders which include reduced sperm count and quality. Post- marketing surveillance also show that Finasteride is known to cause breast tenderness and enlargement, depression, hypersensitivity reactions, testicular pain and even male breast cancer. All of these constitute P F S.   

How Finasteride came to be

Finasteride is a medication used to treat male baldness pattern baldness under the name Propecia and to treat benign prostate enlargement under the name Proscar. The drug was first introduced to the market in the 1980s and was used to treat prostate symptoms at that time. It is only in the 90s that it was discovered to be able to treat male baldness. 

The news of the drugs ability to treat male baldness was much welcome news because before that there were no remedies to male baldness. Finasteride was approved as a hair loss treatment in 1998 by the F D A.

The strange truth though, is that Finasteride was reverse-engineered by the discovery of the consequences of Alpha 5 Reductase Deficiency in hermaphrodite boys in Central American tribes in the 1960's and 70's.

" Another thing that Imperato-McGinley discovered, which would have profound implications for many men around the world, was that the Guevedoces tend to have small prostates.This observation, made in 1974, was picked up by Roy Vagelos, head of research at the multinational pharmaceutical giant, Merck. He thought this was extremely interesting and set in progress research which led to the development of what has become a best-selling drug, finasteride, which blocks the action of 5-alpha-reductase, mimicking the lack of dihydro-testosterone seen in the Guevedoces. "

-The Extraordinary Case of the Guevedoces, BBC Sep 2015  


Finasteride is Regularly Prescribed as a Part of Feminizing Hormone Medication Regimens

Proscar/Finasteride is commonly prescribed to those men who wish to change their gender to female. It is officially a tool in "gender affirming surgery" for transgender women. Of course no medical doctor prescribing Propecia will tell you this. If they did, would you still take it? Also, I wonder if side effects from drugs of this sort contributed to the fatal crash caused by celebrity sex change reality TV star Caitylnn Jenner who continues to undergo hormone treatments for life, as do all transgender people.